Please help on this ERROR

Can someone tell me what should I do whith this error message

'C:\Inetpub\wwwroot\ABC\ABC.mdb' is not a valid path. Make sure that the path name is spelled correctly and that you are connected to the server on which the file resides.We need a little more info on how you are trying to access the file?

Code behind? And maybe a code snipet?

Thanks,

Zath
The file isn't there or the application doesn't have permissions to open the file.
yes I try to access the file by code behide
I think one thread on this subject was enough.